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Kids First: Intracranial Germ Cell Tumors
Kids First Data Resource
Data Resource:  Kids First Data Resource
Point of Contact:  
Allison Heath,  
Project

About This Dataset
Pediatric malignant germ cell tumors (GCTs) represent approximately 6% of childhood cancers, including 3% of tumors in children aged 0-14 years and 15% of tumors in adolescents. GCTs are heterogeneous and grouped together due to the presumed common cell of origin, the primordial germ cell (PGC). GCTs typically occur in the testes or ovaries; however, extragonadal GCTs can occur and are likely a result of abnormal germ cell migration during development. Evidence suggests that GCTs, including those diagnosed in adults, are initiated in utero. Thus, alterations in normal embryonic development are likely to be especially relevant to GCT etiology. Germline susceptibility has not been evaluated in an agnostic fashion in pediatric GCT, mainly due to a lack of an adequate number of samples; however, emerging evidence supports a genetic etiology.
Core Data Elements
Number of Cases
356
Case Sex
Female (159); Male (197)
Case Age At Diagnosis
0 to 4 years (10); 5 to 9 years (22); 10 to 14 years (50); 15 to 19 years (39); Pediatric and Young Adult (<40 years) (235)
Case Race
American Indian or Alaska Native (1); Asian (30); Black or African American (8); Native Hawaiian or Other Pacific Islander (1); Other (24); White (289); Not Reported (3)
Case Ethnicity
Hispanic or Latino (33); Not Hispanic or Latino (320); Not Reported (3)
Case Disease Diagnosis
Intracranial Germ Cell Tumors (356)
Case Proband
Yes (130); No (226)
Number of Samples
356
Sample Assay Method
Whole Genome Sequencing (356)
Additional Data Elements
DBGAP STUDY IDENTIFIER
DATA REPOSITORY
Grant Information
R01CA151284
Molecular Epidemiology of Pediatric Germ Cell Tumors
Charts
Male (197); Female (159)
197Male